Optically activated magnetic recording tape

Optically activated data storage medium visually and electromagnetically reproduces a recorded signal. In an electric field, particles in heat-fluidized thermoplastic layer form a visible image of the recorded signal. Refluidizing the thermoplastic layer erases the signals. Very high data packing densities are achieved

Automated mixed traffic transit vehicle microprocessor controller

An improved Automated Mixed Traffic Vehicle (AMTV) speed control system employing a microprocessor and transistor chopper motor current controller is described and its performance is presented in terms of velocity versus time curves. The on board computer hardware and software systems are described as is the software development system. All of the programming used in this controller was implemented using FORTRAN. This microprocessor controller made possible a number of safety features and improved the comfort associated with starting and shopping. In addition, most of the vehicle's performance characteristics can be altered by simple program parameter changes. A failure analysis of the microprocessor controller was generated and the results are included. Flow diagrams for the speed control algorithms and complete FORTRAN code listings are also included

Automated mixed traffic vehicle design AMTV 2

The design of an improved and enclosed Automated Mixed Traffic Transit (AMTT) vehicle is described. AMTT is an innovative concept for low-speed tram-type transit in which suitable vehicles are equipped with sensors and controls to permit them to operate in an automated mode on existing road or walkway surfaces. The vehicle chassis and body design are presented in terms of sketches and photographs. The functional design of the sensing and control system is presented, and modifications which could be made to the baseline design for improved performance, in particular to incorporate a 20-mph capability, are also discussed. The vehicle system is described at the block-diagram-level of detail. Specifications and parameter values are given where available

Evaluation of ERIM optically processed SEASAT SAR data

The results of three studies on the radiometric and geometric properties of optically processed SEASAT SAR imagery are summarized. The accuracy with which the image scale can be predicted based upon a knowledge of the SAR platform and recording system parameters and the processor characteristics was evaluated. The considerations involved in making radiometric measurements from image films, the use of point targets for calibrating the effects of Doppler spectrum shifts on the radiometric calibration of the SAR image data over extended swath lengths was evaluate

The human milk protein-lipid complex HAMLET disrupts glycolysis and induces death in Streptococcus pneumoniae

HAMLET is a complex of human a-lactalbumin (ALA) and oleic acid and kills several Gram-positive bacteria by a mechanism that bears resemblance to apoptosis in eukaryotic cells. To identify HAMLET's bacterial targets, here we used Streptococcus pneumoniae as a model organism and employed a proteomic approach that identified several potential candidates. Two of these targets were the glycolytic enzymes fructose bis-phosphate aldolase (FBPA) and glyceraldehyde 3-phosphate dehydrogenase (GAPDH). Treatment of pneumococci with HAMLET immediately inhibited their ATP and lactate production, suggesting that HAMLET inhibits glycolysis. This observation was supported by experiments with recombinant bacterial enzymes, along with biochemical and bacterial viability assays, indicating that HAMLET's activity is partially inhibited by high glucose-mediated stimulation of glycolysis but enhanced in the presence of the glycolysis inhibitor 2-deoxyglucose. Both HAMLET and ALA bound directly to each glycolytic enzyme in solution and solid phase assays and effectively inhibited their enzymatic activities. In contrast, oleic acid alone had little to no inhibitory activity. However, ALA alone also exhibited no bactericidal activity and did not block glycolysis in whole cells, suggesting a role for the lipid moiety in the internalization of HAMLET into the bacterial cells to reach its target(s). This was verified by inhibition of enzyme activity in whole cells after HAMLET but not ALA exposure. The results of this study suggest that part of HAMLET's antibacterial activity relates to its ability to target and inhibit glycolytic enzymes, providing an example of a natural antimicrobial agent that specifically targets glycolysis

Expression of Interest ICES/KIS-3 : Thema 4: Hoogwaardig Ruimtegebruik Speerpunt 6

Hoofddoel van dit speerpunt is om zowel de Nederlandse overheid als het bedrijfsleven uit te rusten met een operationele kennisinfrastructuur die toegesneden is op de relatie tussen (antropogene en natuurlijke) klimaatverandering en meervoudig ruimtegebrui